摘要：

The article cites a study which uses a combination of chromatin immunoprecipitation and microarray analysis to explore the histone modifications, transcription-factor binding and nucleosome density in 30 megabytes of human genome. It states that active human promoters were nucleosome-depleted and showed enrichment of trimethylation of Lysx⁴ of histone H3 (H3K4), while enhancers showed enrichment of monomethylated H3K4. It likewise stated that the researchers has integrated these distinct promoter and enhancer chromatin signature into a computational analysis, which made them identify several promoters and enhancers of other genes.

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